NROC69H3 Lecture Notes - Lecture 7: Electrical Resistance And Conductance, Local Field Potential, Classical Conditioning

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Classical conditioning explained by hebbian learning: pavlov and the dog. Is the new field potential the same as baseline: results, slide 8. Ltp in awake, freely moving rabbits: bliss and gardner-medwin 1973, ltp, lasting 3 days (single trains, lasting weeks (multiple trains) Important properties of ltp (cia: cooperativity, when using high frequency stimulation to induce ltp, a crucial number of presynaptic fibers must be simultaneously activated, i. e. they must cooperate to elicit ltp (a threshold stimulation strength must be used) Ltp across single synapses: pairs of synaptically connected ca3 ca1 neurons (in vitro slices, ltp induction, 40 pairings of pre and post synaptic activity, = increase in epsc amplitude. Long term depression: repetitive low frequency stimulation of schaeffer collaterals reduces field potential size. Induction mechanisms: nmda receptors: some forms of ltp depends on activation of nmda receptors, evidence, drugs that block nmda receptor prevent ltp induction without affecting baseline responses, ap5, competitive antagonist, mk-801, non-competitive antagonist, 7-chlorokynurenic acid, glycine antagonist.

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