NROD67H3 Lecture Notes - Lecture 7: Brain-Derived Neurotrophic Factor, Neurofibrillary Tangle, Traumatic Brain Injury
9 Apr 2016
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Menopause, obesity and inlammaion: alzheimer"s disease (christensen & pike) Ab accumulaion (increased producion or decreased clearance) in oligomeric form tau hyperphosphorylaion neuroibrillary tangles. Ad symptoms hypometabolism, bbb disrupion, glial acivaion. The article states that the ad brain is characterized by extensive gliosis, which is the process of swelling of the glial cells in response to injury. This serves to segregate damaged tissue from healthy tissue, however, this process prevents neurons in the damaged tissue from regaining connections to other structures in the nervous system. French paradox french people consume high fat diet but have low incidence of cardiovascular disease resveratrol anioxidant that modulates metal ion deregulaion. Double agent superoxide acts like double agent cause damage cell/proteins/fat which can lead to aging but can also play fundamental role in cell signalling/immunity. Cells need to keep enough antioxidants to prevent damage but cannot have too much antioxidants because can interfere with signalling and immunity.
