NROB60H3 Lecture Notes - Lecture 9: Dentate Gyrus, Anterograde Amnesia, Entorhinal Cortex
Document Summary
Hippocampus (hippo: horse kampos: sea monster sea horse-like structure) Greatest plasticity in the brain, large role in learning & memory. Able to encode new information to make long (declarative) memories (not involved in working / procedural memory) Alzheimer"s disease: hc is the first area to show damage. High seizure susceptibility lowest seizure threshold. Vulnerable to effects of ischemia & hypoxia (periods of blood & oxygen deprivation) Neurofibrillary tangles: found in cerebral cortex and hc. Location and organization of hc & dentate gyrus. Located in temporal lobe, part of the limbic system (involved in learning, emotion & memory) Neuronal cell bodies and zones of connectivity are arranged in orderly fashion. Polymorphic layer / hilus (diffusely cellular, located below) Principal cell layer is made up of pyramidal cells. Ca4 ca = cornu ammonis, ca4 is kind of debatable rn. An internal circuit mechanism unique to the hippocampus. Entorhinal afferents carrying sensory information synapse on granular cells of dentate gyrus.
