NROB60H3 Lecture Notes - Lecture 9: Neurofibrillary Tangle, Seizure Threshold, Sea Monster
Document Summary
Introduction: cytoarchitecture, trisynaptic pathway, learning and memory, hc functions, animal models, long term potentiation. In alzheimer"s disease, this brain area (and its input pathway) is one of the first to show damage. Some cells are withering away, unable to function! Nfts and plaques in normal people, but more in ad. The plaques of alzheimer"s disease are seen here with a silver stain. Such plaques are most numerous in the cerebral cortex and hippocampus. This dementia is marked mainly by progressive memory loss. Anatomical correlates -- neurofibrillary tangles (nfts) are found in both the cerebral cortex and the hippocampus. Location and organization of the hippocampus: located in the temporal lobe, hippocampal formation includes: Part of the limbic system: dentate gyrus, hippocampus proper, subiculum, pre- & para-subiculum, entorhinal cortex. Laminar, structural organization: affected early on in ad, looks like 2 c"s put together! . Pyramidal cells comprise of most of the hippocampus, under golgi stain.
