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Lecture

Hippocampus

4 Pages
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Department
Neuroscience
Course Code
NROB60H3
Professor
Janelle Leboutillier

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Lecture 10 t The Hippocampus
Video: W5 investigates intriguing new theory about MS
x Patients with MS may have a brand new condition aggravating/causing the disease
x High level of toxic iron in brain tissue (causes inflammation and cell death)
o BUT why is it there?
x Uses ultrasound to scan heads and necks of MS patients
x Evidence of narrowing of the vein in MS patients Æ not draining out but flowing back up and
depositing iron there
x What happen if you open block vein?
o Using balloons to repair malformed vein
Hippocampus
x 6 layers in neocortex
What is Hippocampus?
x Large amount of plasticity
o Changes in the brain t makes it adaptable
x Involved in declarative memory (regurgitation of facts)
What is the HC susceptible to?
x Alzheimer[s disease t problems with learning and memory and gets worse with time
o Damage in HC
x Highest seizure susceptibility
x Lowest seizure threshold
o More susceptible to seizure
o Require less change for seizures to occur
x Vulnerable to effects of ischemia and hypoxia
o Ischemia (block blood flow to the brain t lack of oxygen, glucose)
Location and Organization of HC and Dentate Gyrus
x In temporal lobe t towards the base
x Part of the limbic system
x Hippocampal formation includes t larger structure encompasses:
o Dentate gyrus, Hippocampus proper
Hippocampus Pyramidal Cells
x Primarily excitatory neurons
x Effect threshold level
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Description
Lecture 10 J The Hippocampus Video: W5 investigates intriguing new theory about MS N Patients with MS may have a brand new condition aggravatingcausing the disease N High level of toxic iron in brain tissue (causes inflammation and cell death) o BUT why is it there? N Uses ultrasound to scan heads and necks of MS patients N Evidence of narrowing of the vein in MS patients not draining out but flowing back up and depositing iron there N What happen if you open block vein? o Using balloons to repair malformed vein Hippocampus N 6 layers in neocortex What is Hippocampus? N Large amount of plasticity o Changes in the brain J makes it adaptable N Involved in declarative memory (regurgitation of facts) What is the HC susceptible to? N Alzheimer[s disease J problems with learning and memory and gets worse with time o Damage in HC N Highest seizure susceptibility N Lowest seizure threshold o More susceptible to seizure o Require less change for seizures to occur N Vulnerable to effects of ischemia and hypoxia o Ischemia (block blood flow to the brain J lack of oxygen, glucose) Location and Organization of HC and Dentate Gyrus N In temporal lobe J towards the base N Part of the limbic system N Hippocampal formation includes J larger structure encompasses: o Dentate gyrus, Hippocampus proper Hippocampus Pyramidal Cells N Primarily excitatory neurons N Effect threshold level www.notesolution.com
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