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NROB60, LEC05
- for bell-ringer, there is one person at 1 station at a time
- 2 bell-ringer exams (three pins at each station)
- content on LEC06 is not on lab bell-ringer test
- spelling counts (spelling is not a BIG issue)
>- have to pretty close to correct spelling
- print legibly
>- if not readable, then it is wrong
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THIS IS LAST LECTURE BEFORE MID-TERM TEST
(After this, it is all final exam material, with exception of C7 & appendix; if miss mid-
term, then get cumulative exam)
[1]
RESTING NEURONAL MEMBRANE
LECTURE OUTLINE
- SETTING THE STAGE: CAST OF CHEMICALS
- fluid composition
- phospholipid membrane
- proteins
- movemt of ions
- don't need to know Fig3.1 (Simple Reflex)
[2]
CAST OF CHEMICALS
- RESTING MEMBRANE POTENTIAL
- condition where intracellular space (inside surface of memb aka cytosol) has
slight -ve charge relative to outside (extracellular material)
- this occurs at "rest" (no electrical impulses occurring)
- UNDERSTAND THE 3 MAIN PLAYERS
- Salty fluids on either sides of memb.
- Memb
- Memb. proteins
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Questions to Ponder:
- why is there change in charge across memb?
- why at rest is it -ve?
How can we ansser?
- to understand that, need to see
- fluids both inside and outside,
- memb itself, and
- groups of proteins that span across memb
[3]
CYTOSOL & EXTRACELLULAR FLUID
WATER
- [held together] by polar covalent bonds
- effective solvent for
- other polar molec's
- charged molec's or ions
- "key" for being
- the impt ingredient in intracellular & extracellular fluid
- unevenly charged
Consequence of Covalence
- if cov., then shares e-;
- O is more -ve in H2O, so has slightly more -ve charge than H
>- uneven charge => uneven sharing
[4]
CYTOSOL AND EXTRACELLULAR FLUID
IONS
- net elec. charge
- dissolve in H2O b/c charged portions of H2O have more attraction to them, then the
ions to each other
- ie. solute-solute < solute-solvent attractive F's
- SPHERES OF HYDRATION - sphere of H2O molec's surr. each ion
- insulate ions from each other
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Charges
- monovalent (1+, 1-), divalent (2+, 2-) [or even higher]
- Cations => net +ve charge (ex. Na+, K+)
- Anions => net -ve charge (ex. Cl-)
Example: why does salt (NaCl) dissolve in water?
- b/c what happens w/ cov. H2O molec is that it surr. individual ions in NaCl
- have Cl- ion surr. by sphere of H2O molec's, and also for Na+
- H2O insulates the ions from each other and it turns out that ions are more attracted to
water molec's than they are to each other
(insulation occurring here for Cl-, as well as Na+; this is what is meant by them
dissolving)
[5]
WHY ARE IONS IMPORTANT?
IONS
- are MAJOR CHARGE CARRIERS involved w/ conduction of electricity in biol sys's
- this includes neurons
- particularly impt for cellular neurophysiology are the following
- Na+ (sodium; monovalent cation)
- K+ (potassium; monovalent cation)
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Document Summary

For bell-ringer, there is one person at 1 station at a time. 2 bell-ringer exams (three pins at each station) Content on lec06 is not on lab bell-ringer test. Spelling counts (spelling is not a big issue) >- have to pretty close to correct spelling. >- if not readable, then it is wrong. This is last lecture before mid-term test (after this, it is all final exam material, with exception of c7 & appendix; if miss mid- term, then get cumulative exam) Don"t need to know fig3. 1 (simple reflex) Resting membrane potential slight -ve charge relative to outside (extracellular material) Salty fluids on either sides of memb. Condition where intracellular space (inside surface of memb aka cytosol) has. This occurs at rest (no electrical impulses occurring) Groups of proteins that span across memb. Dissolve in h2o b/c charged portions of h2o have more attraction to them, then the ions to each other.

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