Class Notes (1,100,000)
CA (650,000)
UTSC (30,000)
NROB60H3 (100)
Lecture

NROB60 LEC07 LeBout Summer 2012


Department
Neuroscience
Course Code
NROB60H3
Professor
Janelle Leboutillier

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NROB60 LEC07
SYNAPTIC TRANSMISSION - CHAPTER 5
[1]
- LAST Wk: how info is passed on w/in neuron
- now: how info passed b/ween neurons
[2]
LECTURE OUTLINE
TYPES OF SYNAPSES
-
ELECTRICAL
- CHEMICAL
CHEMICAL SYNAPTIC TRANSMISSION
SYNAPTIC INTEGRATION
[3]
INTRODUCING THE SYNAPSE
- SYNAPTIC TRANSMISSION
- process of info being passed on from 1 cell to another at synapse
- DIRECTION OF INFORMATION FLOW
- Unidirectional: neuron to target cell
- First neuron = presynaptic neuron
- Target cell = postsynaptic neuron
[4]
WEBSITE
(not will be tested on)
[5]

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ELECTRICAL SYNAPSES
- widespread thro brain but rare
- found in all pts of brain ex. amydala, hipocampus, cerebral cortex, just few in quantity
- narrow cleft (=
gap junction
); only 2-4nm
- if you have direct flow of ions from one cytoplasm to another cytoplasm, then you say those
participating cells are "electrically coupled"
- large channels on memb's
-
connexon
= 6 connexins put together
- synaptic transmission resembles axonic conduction
- appears as if info is passed on like in AP
- little delay
=> v.quick => this is what makes this synapsis advantageous
- freq. found in neural circuits involved w/ escape behavi., or others that req. an instantaneous
response
[6]
ELECTRON MICROGRAPH OF AN ELECTRICAL SYNAPSE
- A of synapse
- much closer together
- hard to identify

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[7]
SCHEMATIC OF ELECTRICAL SYNAPSE
- interacting neurons v.close together
- only about 3.5nm apart from each other
- connexons from one neuron lined on top of connexons from the one it is interacting with
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