NROB60H3 Lecture Notes - Lecture 6: Axon Terminal, Sensory Nerve, Pharmacology

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The action potential: in theory, in practice. Will not be tested on box 4. 2. Resting potential is the consequence of the differential concentrations of ions inside and outside: the neuron, the semipermeable nature of the membrane. Membrane is primarily permeable to k ions: when equilibrium is reached between. The diffusion pressure forcing k out of the cells. The electrostatic pressure forcing k into the cell. Neurons must actively maintain this ion balance via the na/k pump due to the gradual leakage of ions across the membrane. The ups and downs of an action potential: observed using an oscilloscope. 5 animation of action potential by voltage gated na channel. In order to study how action potentials are generated: first insert two electrodes into the neuron. Insufficient stimulation (i. e. lower than threshold) does not result in action potential. Sufficient stimulation (equal or higher than threshold) results in action potential. Hyperpolarizing potential drives membrane voltage in negative direction.

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