NROB60H3 Lecture Notes - Lecture 7: Curare, Skeletal Muscle, Neuroglia

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Synaptic transmission: the process of information transfer at a synapse. Direction of information flow: in one direction. Neuron to target cell: first neuron = presynaptic neuron, target cell = postsynaptic neuron. Narrow cleft (gap junction: 2-4 nm. Cells are said to be electrically coupled: flow of ions from cytoplasm to cytoplasm. Frequently found in neural circuits such as escape behaviour: fight or flight. Dendrite to dendrite: gray"s type i. Basic steps: neurotransmitter synthesis, load neurotransmitter into synaptic vesicles, vesicles fuse to presynaptic terminal, neurotransmitter spills into synaptic cleft, binds to postsynaptic receptors, biochemical / electrical response elicited in postsynaptic cell, removal of neurotransmitter from synaptic cleft. Video summary: presynaptic neuron postsynaptic neuron, typical chemical synapse in the cns. Synaptic transmission begins when the nerve impulse reaches the presynaptic axon terminal. Depolarization of the presynaptic membrane initiates the sequence of events that result in transmitter release towards the postsynaptic membrane. Principle molecules and organelles required for release of neurotransmitter.

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