NROC61H3 Lecture Notes - Lithium Chloride, Attention Deficit Hyperactivity Disorder, Olanzapine
Document Summary
The role of dopamine and serotonin in anorexia nervosa: [1] fladung, a. k. , gr n, g. , grammer, k. , herrnberger, b. , schilly, e. , grasteit, s. , wolf, r. c. , walter, h. , von wietersheim, j. (2010). A neural signature of anorexia nervosa in the ventral striatal reward system. Fladung et al. observed activity of the ventral striatum via functional magnetic resonance imaging in women with acute anorexia nervosa. They observed that the anorexia nervosa participants showed significantly higher activation in the ventral striatum when processing visual stimuli that presented underweight individuals. These results are significant because they agree with animal study findings in that the ventral striatum reward pathway, which includes dopaminergic neurons, plays a role in anorexia nervosa. The authors examined activity in the ventral striatal system in response to disease-specific stimuli in women with acute anorexia nervosa. Participants were required to process each stimulus in a self-referring way. Ratings for each weight category were used as the control task.
