PSYB32H3 Lecture Notes - Lecture 12: Primary Progressive Aphasia, Semantic Dementia, Meningitis

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12 Aug 2016
School
Department
Course
LEC 12 - Aging and psychological disorders
Dementia – gradual deterioration of intellectual abilities
- Step wise cs. Slowly progressive
- Impairment in social and occupational functioning
oCognitive reserve – memory, learning, etc. – higher in men but functional reserve is
higher in women
- Each dementia syndrome has a unique neuropsychological signature
- Diagnosis is clinical - but just probability
- Only at autopsy can it be definitive
Alzheimer’s disease
- Characteristics
oUsually begins after 65 years old
oSlowly progressive
oEarly onset that is more progressive than the late-onset that develops after 65
oDeath after 8-10 years – usually as the result of physical decline or independent diseases
common in old age, such as heart disease
oMost common type (55-80% of all dementias)
- Neuropathology – starts in parietal and temporal lobes
oFilaments within nerve cells in brain were twisted and tangled (called neurofibrillary
tangles)
oPlaques - deposits of a class of protein called amyloid that accumulate in the spaces
between cells of the cerebral cortex, hippocampus, and other areas of the brain
structures critical to memory
o
- Neuropsychological progressive – memory, naming, visuospatial disorder
oExplicit memory impaired because of inability to consolidate
oWorking memory relatively intact – frontal lobes are not impaired
oProcedural memory relatively intact
oRetrieval impaired
oRecognition impaired
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