PSYB65H3 Lecture 4: Lecture 4.docx
Document Summary
High concentration of sodium ions on the outside of the neuron. Goes from high density to low density = will travel from the outside to the inside. Makes the inside of the cell more positive. Possible places where we can interfere with the systems: synthesis. If you want to make more dopamine, for example, you could increase synthesis. If you want to slow it down: find an enzyme that could slow it down: storage. Nt has to be stored or packaged inside the vesicle: release. Whenever ap comes along, the vesicle merges with the presynaptic membrane and the nt is released into the synaptic cleft: receptor. Nt interacting with the receptor: inactivation - breaking it down and destroying it, reuptake - taking it into the presynaptic cell. Need to increase the functional activity of dopamine. Need to decrease the functional activity of dopamine. Schizophrenia (we need to decrease the functional activity) Nts would continue to activate receptor until gone.
