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Ted Petit (310)
Lecture

note 04 - neurotransmitter

2 Pages
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Department
Psychology
Course Code
PSYB65H3
Professor
Ted Petit

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life cycle of neurotransmitter
-systhesis
being synthesized by 'ingredients' from body and brain
-storage
transmitter is packaged and float in the axon
*critical*: if no package to prevent, transmitter will be destroyed by other chemicals before it
moves to pre-synaptic membrane
-release
packged neurotransmitters move toward the pre-synaptic membrane and transmitters are released
from package to synapse
-receptor interaction
transmitter interact with receptor, if active, the ion channel of post-synaptic cell will open,
information can be transmit to next cell
*many problems can happen at this stage
-inactivation
reaptake: take the transmitter back to pre-synaptic cell
degradation: breakdown/destroy the transmitter
dopamine system not working --> Parkinson's disease
dopamine system over working --> Schizophrenia
functional activity of nervous system
-can either increase or decrease neuro activities (often use drugs)
-can take place at all stages of transmitter life cycle
*increasing activity of synthesis stage with drugs affect obviously in treating Parkinson's disease
(using dopa to increase synthesis of dopamine)
*to increase or decrease activity level at receptor interaction stage, two kinds of chemicals can be
used
-they all similar to transmitters
-mimic: increase interaction when being packaged and released with transmitter
-blocker: decrease interaction by b eing released to synapse but doing nothing so that ion channel
can't open (block the ion channel)
classic neurotransmitters
MONOAMINES: inactivated through reuptake
catecholamines
-dopamine(DA), norepinephrine(NE)
-synthesized from tyrosine -> dopa -> DA -> NE
seratonin(5HT)
-synthesized from tryptophan -> 5OHT -> 5HT
ACETYLCHOLINE(ACL): breakdown by ACLE
-choline + acetylcoa -> ACL
abnormality in phisiology of brain -- epilepsy
-repetitive discharge of hyperexcitable aggregation of neurons
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Description
life cycle of neurotransmitter -systhesis being synthesized by ingredients from body and brain -storage transmitter is packaged and float in the axon *critical*: if no package to prevent, transmitter will be destroyed by other chemicals before it moves to pre-synaptic membrane -release packged neurotransmitters move toward the pre-synaptic membrane and transmitters are released from package to synapse -receptor interaction transmitter interact with receptor, if active, the ion channel of post-synaptic cell will open, information can be transmit to next cell *many problems can happen at this stage -inactivation reaptake: take the transmitter back to pre-synaptic cell degradation: breakdowndestroy the transmitter dopamine system not working --> Parkinsons disease dopamine system over working --> Schizophrenia functional activity of nervous system -can either increase or decrease neuro activities (often use drugs) -can take place at all stages of transmitt
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