PSYC12H3 Lecture Notes - Signal Transduction, Cyclic Adenosine Monophosphate, Phosphorylase

13 views4 pages
Published on 19 Apr 2013
School
UTSC
Department
Psychology
Course
PSYC12H3
Question 1 - 642
You have been actively studying various signals produced within baby chimps. One day, you observe a ligand bind to a
G-protein coupled receptor. You find out that the ligand is responsible for a deadly signal which could potentially kill the
chimp. Since you are a caring and compassionate scientist, you are thriving to save this baby chimp. What can you do to
stop the signal from being produced?
Increase GRK(G-protein receptor kinase) levels
Increase GDI(Guanine nucleotide dissociation inhibitors) levels
Decrease GAP(GTPase activating proteins) levels
Increase GEF(Guanine nucleotide exchange factors) levels
Both A and B
A. Correct; by increasing GRK, arrestin will bind to the receptor thus keeping the G-protein inactivated
Question 2 - 645
Below is a list of steps involved in the signal transduction pathway of glycogen metabolism. Order the steps that have
been listed and select the fourth.
G protein activates of adenylyl cyclase
cAMP activates protein kinase A
Hormonal signal and receptor activation
Many cAMP molecules are produced amplifying the signal
PKA (protein kinase A) phosphorylates glycogen synthase and phosphorylase kinase
Question 3 - 614
Which of the following process(es) can cAMP affect?
Fatty acid formation.
Assembly and disassembly of microtubules.
Glycogen formation.
All of the above.
None of the above.
Question 4 - 638
Identify the correct order of steps for the signal transduction pathway of glucose metabolism: 1) cAMP activates protein
kinase A, 2) Hormonal signal and receptor activation, 3) PKA phosphorylates many targets, including both phosphorylase
and glycogen synthase, 4) Many cAMP molecules are produced, 5) G protein activation of adenylyl cylcase
2,5,4,1,3
2,4,5,1,3
Question 5 - 630
Which of the following statements with regards to G-proteins and glucose metabolism is/are TRUE?
Glucose can be used for energy by glycogen glucagon, or stored by glycogen insulin
cAMP molecules are not produced, since the hormones involved in glucose metabolism do not bind to
membrane-bound receptors of target cells (i.e. taken into cell by endocytosis)
Enzymes involved in glucose metabolism are governed by the presence of hormones
Glucocorticoids and epinephrine induce the same response of a target cell prior to glucose metabolism
Question 1 - 647
State which of the following statements on G-proteins and their signaling pathway is true.
G-protein is a heterodimer whose three sub units act as anchors to the membrane since they are linked to the
membrane bound lipids
The receptor changes it structure once the ligand binds to its extracellular domain, which allows it to bind to the
G-protein
The G-protein has two sub units which posses GTPase activity
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Document Summary

You have been actively studying various signals produced within baby chimps. One day, you observe a ligand bind to a. You find out that the ligand is responsible for a deadly signal which could potentially kill the chimp. Since you are a caring and compassionate scientist, you are thriving to save this baby chimp. Both a and b: correct; by increasing grk, arrestin will bind to the receptor thus keeping the g-protein inactivated. Below is a list of steps involved in the signal transduction pathway of glycogen metabolism. Order the steps that have been listed and select the fourth. G protein activates of adenylyl cyclase camp activates protein kinase a. Many camp molecules are produced amplifying the signal. Pka (protein kinase a) phosphorylates glycogen synthase and phosphorylase kinase. Enzymes involved in glucose metabolism are governed by the presence of hormones. Glucocorticoids and epinephrine induce the same response of a target cell prior to glucose metabolism.

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