PSYB64H3 Lecture 6: Human Brain – Lecture 6.docx
Document Summary
Schizophrenia > very debilitating: hallucinations/delusions, affective disorders > persons is extremely depressed/maniac. Genetic predisposition is there but there are other factors as well [not 100%: 9/12 siblings still schizo > when monozygotic twins separated at birth, most used in the early days: phenothiazines [class] > chlorpromazine. 4mnths if the person is bipolar > the lithium doesn"t just control the mania but also the depressive stage [maybe the depressive stage is a reaction to the maniac phase] Depression > cycles of mania and depression > bipolar disorder reduction in the monoamines > reserpine: causes the monoamines to leak from the synaptic vessels, this caused depression. Maoi, monoamine oxidase inhibitor > led to a increase in monoamines > reduced depression. *increasing monoamines [particulary serotonin, norepinephrine] effective in treating depression takes 8 days > to actually effect patients beh [but the transmitter levels are effected w/i hours]
