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Lecture 7

Lecture 7.docx

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University of Toronto Scarborough
Ted Petit

Lecture 7 Mechanisms of drug action, psychopharmacology of neural stimulants. GENERAL INFO terms related to EVERY drug  HOW DRUGS ARE CLASSIFIED? o PRESCRIPTION DRUG  You NEED a prescription o OVER THE COUNTER DRUGS  You get it from a pharmacy but you DON’T NEED a prescription o SOCIAL DRUGS  Nicotine, caffeine, alcohol  You can get them  You don’t have to go to a drug store o Drugs which are not produced for their psychoactive effect  You cant just go to ANYONE and buy them  Marijuana, LSD  Then there are drugs that are produced and you can buy them  Airplane glue  TOLERANCE o The concept that f a drug is taken repeatedly, most drugs show a decreasing behavioral effect o The more you take it, the less effect it has. o The more you stimulate/ alter a system, the post synaptic side of the system will compensate by reducing either the number or sensitivity of the receptors until it reaches a level of equilibrium o If you use something that slows a system down like depressants, the system will compensate by increasing the sensitivity.  WITHDRAWAL o If you have been taking the drug for A LONG PERIOD OF TIME and stop taking it  You have a craving for the drug o The behavioural effect:  Opposite of the behavioural effect when the person is on the drug  It’s going to understimulate the postsynaptic cell from being happy to sad  Its not going to back to base line but beneath the baseline and then finally go back to baseline.  For depressants: the activity increases from sad to happy  It’s going to go up above the baseline and then come back down to baseline. o Generally not life threatening. o Sometimes can be life threatening for alcoholics never take them off it directly substitute valium gradually lower it  ADDICTION o Person enjoys and becomes dependent upon the drug o The more rapid the effect of the drug, the more addicting it is general rule o In mild forms it is not addictive its slow and goes through the system slowly; there is no rush o But if the exact same chemical is taken in a more powerful and rapid effect can become addictive. o o PSYCHOLOGICAL ADDICTION  Has become behaviorally dependent on the drug very much attached and its hard for them to give it up  No physical changes o PHYSICAL ADDICTION  On withdrawal, there has to be some physical withdrawal symptoms something you can measure numerical data STIMULANTS  By definition have to activate the central nervous system  Depressants will depress the activity  All the stimulants cause the EEG to switch to an arousal state and inhibit sleep CAFFEINE  Found in coffee and tea; tea has less than coffee  Inhibits sleep  Speeds up digestive process, relieves headache TOLERANCE  Some tolerance, very low WITHDRAWAL  Have headaches  Constipation  You have to be a 6-8 cups of coffee a day for a long period of time to have these withdrawal symptoms TOXICITY  Not very toxic  70-100
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