Class Notes (835,428)
Canada (509,186)
Psychology (7,782)
PSYB65H3 (519)
Ted Petit (310)
Lecture 8

Lecture 8.docx

4 Pages
Unlock Document

Ted Petit

Lecture 8 Pharmacology of drug action, depressants, opiates and hallucinogens DEPRESSANTS work through GABA primary inhibitory amino acid neurotransmitter in the brain decrease activity in the brain Classifications  Barbiturates o Help people sleep and relax o Work by binding to GABA receptors in the brain o Inhibit the brain and decrease excitability in the brain o It is also synergistic with other sedatives and also anxiolytics and anticonvulsants  share the mechanism to slow things down  Synergistic: if you put them together they are additive; they are not independent they add to each other (they also multiply)  combined effect being greater than parts  Its very dangerous to mix barbiturates and alcohol because they are synergistic o Sedative  puts you to sleep or called hypnotic when you stay awake after taking it o Anxiolytics take away anxiety; calm down o Anticonvulsants stop seizures slow down the excitation during the epilepsy o The biggest group used for were the elderly as you mature, sleep patterns become irregular because they wake up their REM sleep and they don’t feel very rested o Withdrawal: when you come off of them you get potential seizures depending on for how long and how much doses were you taking never taking anyone directly off depressants potential death you can replace it with other barbiturates or alcohol (help with the withdrawal)  Non barbiturates o  Alcohol o A CNS depressant o Produced by yeast, digesting sugar and excreting alcohol o Problems:  Largest admissions to a psychiatric hospital 40% of all patients in a psychiatric hospital are alcoholics  Accounts for 55% of all arrests  50-75% of all murder, homicides, one of the parties was drunk  50% of all driver’s dead, one of the 2 parties was drunk  20-30% of all suicides, the person was drinking at the time  In the U.S  Jan 1920 to Dec 1933 prohibit the sale of alcohol  Initial drop in all the alcohol related problems  By 1930 all the numbers were right back up where they were before the prohibition and in addition they had other problems as people were making a lot of alcohol instead of making ethyl alcohol (people drink), they were drinking methyl alcohol leads to blindness (wake up the next morning blind permanently or die for high doses)  Lesson: o If people really really want a drug, they will find a way to find it and do it. o Instead of preventing the people from doing it, they started educating people so they would understand o PHYSIOLOGY  It is absorbed directly through the stomach wall, unlike most other things, that has to be broken down  A very high source of energy and the fastest source of energy as it goes right past the stomach wall  200 calories per ounce or 7 calories per gram  Cannot enter any metabolic pathway whereby it can be stored as fat.  If all you do is alcohol you cannot get fat, but with food  It causes the brain to decrease the production of ADH excrete more fluids than you take in leads to dehydration o How it works:  Works on GABA receptors  Slowing metabolic activity within the neuron  Through membrane excitability o Behaviours  Depends on the dose level  At low doses (1-2 drinks): causes a disinhibition of the cortex it depresses inhibitory centres shifts to an arousal state reasonably low levels of alcohol  At high doses: direct depressant effect on the CORTEX sloppy, stagger, slurring their words if you take enough it does depress the activity of medulla and can eventually kill you  There is a point where when
More Less

Related notes for PSYB65H3

Log In


Join OneClass

Access over 10 million pages of study
documents for 1.3 million courses.

Sign up

Join to view


By registering, I agree to the Terms and Privacy Policies
Already have an account?
Just a few more details

So we can recommend you notes for your school.

Reset Password

Please enter below the email address you registered with and we will send you a link to reset your password.

Add your courses

Get notes from the top students in your class.