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PSYB65H3 (519)


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Zachariah Campbell

Neuronal physiology, epilepsy action potential- “na comes into neuron, brings positive charge, causes cell to become very positive until channels close and get sodium out of cell” crosses synapse chemically not electrically transmitter substances each of the following steps provide opportunity for us to interfere/make changes 1. synthesis: some mechanism of making these chemicals we can stop things from being synthesised or synthesise more 2. packaging/ storage interfere with ability to store it 3. release: we can increase release or block release 4. receptor: we can block the receptor amphetamines can fit in receptor without even an AP 5. inactivation (really breakdown) 6. reuptake (also considered inactivation) you NEED to have a way of inactivation so that u can activate neuron again 7. degradation how can drugs increase or decrease functional activity of neurotransmitter system synthesis: activity is too low: you want to increase synthesis synthesis: activity is too high: you want to decrease synthesis storage: n/a storage: activity is too high: you want to decrease packaging release: too low: increase release release: too high: decrease release receptor activity: too low: increase receptor activity mimicker: directly activates receptor (amphetamine) receptor: too high: decrease receptor activity blockers: sit on receptor site to block it but do not activate it inactivation (destroying or reuptake): if activity in system is too low(parkinson’s): reduce inactivation: transmitter hangs around longer inactivation: activity in system is too high: increase inactivation transmitter systems biogenic amines (aka monoamines) subgroups: catecholamines (dopamine DA, norepinephrine NE) and serotonin DA and NE synthesised from tyrosin dopadopaminenorepinephrine parkinsons disease has not enough dopamine treatment: dopa (precursor to dopamine serotonin synthsised from typtophan SDHTSHT 5HT (serotonin) biogenic amines inactivated by reuptake!!!! acetylcholine ACL synthesised from choline+acetyl CoA inactivated by being broken down by acetylcholineesterase epilepsy epilepsy: a repetitive discharge of a hyperexciteable collection of neurons they fire repetitively instead of every cell doing it’s own thing, they all start doing the same thing over and over at the same time because one little collection is so exciteable it causes all other neurons to become excited as well and they all end up doing the same thing repetitively related to memory: in memory, synapses become more easy to fire when they are used more often in epilepsy, this happens to the whole cortex until the whole cortex is firing at the same time convulsions: body convulses, not brain, motor….? etiology of eplilepsy some people are predisposed to it genetically can usually tell cause by age of onset if before 20 usually birth trauma: often hypoxia: lack of oxygen at birth or birth defect,metabolic errors, biochemical abnormalities, infectious di
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