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PSYB65H3 (519)
Lecture 7

Lecture 7 PSYB65.docx

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John Campbell

Lecture 7 PSYB65  Drug – any chemical you can use and ingest, very specific classes of drugs  Types: o Prescription drugs o Over the counter drugs – from drugstore without prescription (Codine -canada) o Social drugs – nicotine, caffeine, alcohol o Can go out and buy these, not produced for their psychoactive effect (glue) o Cant go out and buy these (marijuana)  Tolerance o Concept that if a drug is taken repeatedly most drugs shows decreasing behavioral effect o Mechanism - if you have drugs that alter a system, postsynaptic side compensates by reducing number or sensitivity of receptors o Ex. Depressant slows down system, system will compensate by increasing sensitivity and number of receptors  Withdrawal o If you’ve been taking drug for a long period of time, then suddenly stop, you have a craving for it o Behavioural effect is opposite of effect of drug itself  Stimulant  compensated with lesser receptors….withdrawal=stimulant is gone…pre- synaptic axon is now putting out regular amount of transmitter…only one receptor though? No effect on postsynaptic cell because sensitivity is too low…persons activity levels are really down/understimulated o If someone is on stimulants and go through withdrawal, they’ll be tired, lethargic, sad –not life threatening o Depressants – on withdrawal, brain is hyperexcitable, can cause seizures, agitation – can cause death (alcohol)  Addiction o Persons enjoys and is dependant upon drug, different types o Psychological addiction – person is behaviorally dependant on drugs, not as meaningful o Physical addiction – on withdrawal, there has to be some physical withdrawal symptoms (sweating, seizures) o More rapid the effect of the drug, the more addicting it is  Stimulants o Drugs that have to activate CNS o All stimulants cause cortical EEG to switch to an arousal state o Inhibit sleep o Caffeine – inhibits sleep, headach
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