Class Notes (806,749)
Canada (492,425)
Psychology (7,610)
PSYB65H3 (519)
Ted Petit (310)


6 Pages
Unlock Document

University of Toronto Scarborough
Ted Petit

Lec04 Outline  Basic neurology of neurons and how they transmit information  How to alter systems to increase or decrease activity o Parkinsons  affects dopamine to be depressed  Trouble walking / moving o Schizophrenia  affects dopamine to be overactive  What is dopamine?  What do we do in neuroscience o Deal with diseases of the brain such as parkinsons / schizophrenia o Understand systems to evaluate drugs that can cure / treat these diseases Basic concepts  Neurons are cells o Communicate information o Has a membrane with channels  High amounts of sodium outside of the membrane  When it enters the cell, makes the cell more positive o If it hits a threshold  triggers and fires an action potential  Firing of action potential  opens all the sodium channels  High amounts of potassium inside the membrane o Channels open up when electrochemically stimulated o Resting membrane potential is slightly negative o Starts at axon hillock  fires down axon  towards nerve terminals  towards synapse  towards dendrite  Presynaptic axon  postsynaptic dendrite  Inbetween is the synaptic cleft o Synaptic vesicles contain neurotransmitters that transmit information  What happens when you get an action potential? o Potential reaches presynaptic membrane o Releases synaptic vesicles into synaptic cleft o Interacts with receptor site o Stimulates changes on the post-synaptic membrane  New action potential firing  All-or-none Neurotransmitters  Life cycle of a neurotransmitter. o Synthesis o Storage o Release o Receptor interaction o Inactivation  Reuptake and restorage  Degradation Parkinsons  Need drugs that increase the functional activity of the dopaminergic system o Increase  Synthesis  Amount of neurotransmitter release  Increased receptor activation  Mimicry  Does the function of a neurotransmitter but is not the same neurotransmitter o Decrease  Inactivation Schizophrenia  Need drugs that decrease the functional activity of the dopaminergic system o Decrease  Synthesis o Prevent  Packaging  Release from presynaptic membrane  Receptor activation o Increase  Inactivation  Blockers o Chemicals that are similar to the neurotransmitter, but not similar enough  binds to receptor channels  does not activate it  Degradation  Reuptake Classes of neurotransmitters  Monoamines o Biogenic amines  inactivation by reuptake  Catecholamines  Dopamine (DA)  Norepinephrine (NE)  Synthesis o Tyrosine  Dopa  DA  NE  Serotonin (5-HT)  Synthesis o Tryptophan  5OHT  5HT  Acetylcholine o Inactivation by breakdown  Acetylcholinesterase (AChE) o Synthesis  Choline + Acetyl CoA  Ach  Precursors are needed to make neur
More Less

Related notes for PSYB65H3

Log In


Don't have an account?

Join OneClass

Access over 10 million pages of study
documents for 1.3 million courses.

Sign up

Join to view


By registering, I agree to the Terms and Privacy Policies
Already have an account?
Just a few more details

So we can recommend you notes for your school.

Reset Password

Please enter below the email address you registered with and we will send you a link to reset your password.

Add your courses

Get notes from the top students in your class.