Question 1 - 496
Which statement about condensin is incorrect?
The complex is built around a pair of SMC subunits
Forms a ring around supercoiled loops of DNA within chromatin
Aids in the compaction process as the cell enters mitosis
Encircles DNA helices just after replication
Cooperative interactions organize the supercoiled loops into larger coils
A. This statement about condensin is true.
B. This statement about condensin is true.
C. This statement about condensin is true.
D. This action is performed by cohesin, not condensin.
E. This statement about condensin is true.
See figure 14.14 for more details.
Question 2 - 490
The Dam1 ring:
Slides along MT and aids in the movement of chromosome during anaphase
Positions spindle and determines plane of cytokinesis
Is anchored to kineotochore, thus maintaining contact with the chromosome as the MT is depolymerizing
Both a and c
None of the above
Question 3 - 520
Which of the following is/are the general function(s) of cyclins - aka CDK complexes
Capture a chromosome at the centromere and move it to a pole
Organise chromatids into super-coiled loops
Promote cell cycle progression
Drive chromosomes along microtubule tracks
Two of the above are correct
Question 4 - 519
There is a mutation in the gene encoding the Dam1 ring, making it useless. What can result from this problem?
Chromosomes do not move to the poles during anaphase.
Cell does not divide to 2 cells poles are not seperated
Both B and D
Question 5 - 484
In order for the M phase of the cell cycle to occur, what steps must be initiated?
The cytoskeleton must undergo dramatic reorganization.
Chromosomes must be condensed.
The breakdown of the nuclear membrane must occur.
A and C.
All of the Above.
Question 1 - 527
1. During ____________ , ___________ maintains linkage between sister chromatids. During _________ ,
_____________ is involved in formation of supercoiled loops and bringing the supercoiled loops close to one another
Interphase, Condensin, Prophase, Cohesin
Prophase, Cohesin, Interphase, Condensin
Interphase, Cohesin, Prophase, Condensin
Interphase, Cohesin, Interphase Condensin
Prophase, Cohesin, Prophase, Condensin
Question 2 - 515
Which of the following about kinesin is/are true?
Contains a plus end-directed motor protein.
Contains two dynein heavy chains.
Family member of kinesin-like proteins.
Both A and C.
All of the above.
Question 3 - 512
Which of the following events aid in the poleward movement of sister chromatids during anaphase
Loss of tublin from polar microtubules
Loss of tubulin from kinetochore microtubules
Addition of tubulin to polar microtubules
Addition of tubulin to kinetochore microtubules
B and C are correct Question 4 - 486
What is a kinetochore?
A molecular motor which drives chromosomes along microtubule tracks in the direction of the minus-end.
A condensin like complex that holds sisters together.
Binding sites for microtubules which are formed by proteins associated with repetitive DNA at the centromere.
A molecular motor which drives chromosomes along microtubule tracks in the direction of the plus-end.
Binding sites for microtubules which are formed by proteins associated with repetitive RNA at the centrioles.
Question 1 - 523
During mitosis, the mechanism by which kinetochores can hold onto the plus end of the microtubule that are losing
tubulin subunits have been studied in budding yeast. Each kinetochore is believe to have a Dam1 protein complex. Of the
following options regarding Dam1, which is correct?
Dam1 inner diameter is 32 nm.
Dam1 assembles to form rings that encircle the microtubules.
Dam1 proteins are found in animal cells.
A and B.
A and C.
D. Correct; Answer A and answer B are correct. Figure 14.30, pg.583
Question 2 - 518
Which of the following statement about microtubule motors is true?
Myosin V is a plus-end director
Myosin II is a plus-end director
Kinesin is a plus-end director
Dynein is a plus-end director
Both B and C
Question 3 - 494
Which of the following structure is responsible for organizing chromatin into supercoiled loops?
Cyclin dependant kinase
Question 4 - 506
Which of the following is NOT an effect of MPF in moving a cell into M phase? phosphorylation of lamins, breaking down of nuclear membrane
phophorylation of MT associated proteins (microtubule associated proteins)
chromosome condense through cohesin/condensin targets
DNA synthesis occurs
All of the above
Question 5 - 501
Suppose there is a mutation in the mRNA encoding for Cdc25 phosphatase, such that it is unable to remove the inhibitory
phosphate on the Tyr 15 residue of the cyclin-CDK complex. What is a direct effect of this MPF complex being rendered
S phase of the cell cycle will not occur
Chromatin will not condense