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Lecture 4

LEcture 4 Placebo.docx

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Michael Bagby

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Give a placebo bec. It deals with the notion that you’re controlling the fact is given something Psychological mental things that one respond to placebo – Expectation that giving a drug and respond to that expectation that symptoms ging to be releved or not Open label clinical trial – get Prozac, x number of mg. placebo – know you’re gonna get Unethical from group that withholding Tri council guidelines – agencies for physical,social biological, natural science research - Prohibits use of placebo trials if know treatments are present Paper: tricouncil guidelines and find the exceptions and incorporate in treatment Psychiatrist or physician have many treatments as you can in your disposal Open label placebo Fluoxitine – Prozac – phizer – their trial big put many people in Prozac trial only way to got in placebo group and when try to replicate they couldn’t replicate - so need placebo trial so ironic bec. Tri council prohibit this More subjects more statistical power –higher probability that detect small diff. in groups – massive but many people respond in placebo Placebo response as high as 40% - less depressed sub threshold than when they started Separation bet. Placebo group some people sometimes respond to placebo Do you think get same results - open label – know what they’re getting Why is that more ethical? Mild –moderate dep. Placebo respond well to open label and treatment and replicate then placebo get same as placebo Harder to show change when moderate bec. Not much room to change For: Validate the efficacy of a drug Need placebo to be approved by DFA Less side effects Cheaper – cost money bec. Placebo study requires less subject
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