ANA300Y1 Lecture Notes - Lecture 9: Mucosa-Associated Lymphoid Tissue, Tonsil, Axillary Lymph Nodes

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16 Oct 2014
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Lecture 9: the lymphatic system. Mucous membranes lines all passageways that open to exterior: digestive, respiratory, reproductive, urinary tracts form a barrier to pathogens. Larger lymphatic vessels smaller lymphatic vessels joins the larger ones similar to veins, valves closer together thin walls, collapsed. Lymph drains into venous blood. Memory t cells second exposure elicits more rapid and severe response basis of vaccines. T cell activation requires the antigen be presented on the surface of an antigen- presenting cell (apc), such as a macrophage. Can recognize antigen directly, i. e. without the help of apcs. T & b cells are responsible for specific immunity. With antigen exposure, differentiate into plasma cells. Requires cytokines produced by activated helper t- cells. Plasma cells produce, secrete antibodies, largely in response to bacteria. Thus responsible for antibody- mediated or humoral immunity (fluids) Binds antigen and marks it for phygocytosis. Antibodies: soluble proteins; bind antigen on subsequent exposure, mark it for phagocytosis.

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