Lecture 16 Notes

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7 Jun 2011
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BIO120
LECTURE 16: MEASURING GENETIC DIVERSITY
Fisher & Haldane: quantitative aspects of evolutionary change; population genetics into evolution
Wright: mendelian law, natural selection, and continuous variation – mathematical
Synthesis of ecology (Darwinian natural selection and genetics)
Theory of impericism.
Not all genes are variable
What forces influence diversity?
Mutation
Recombination
Random genetic drift ( small population size effects)
oCan lead to reduction in diversity
Natural selection
oPurifying ( negative)reduce fitness removed by selection
oPositive selection (adaptation)mutatuion arises and is favoured.
oBalancing selection – heterozygotes are favoured over homozygotes
Fisher felt that all important evolution occurred in large population by natural selection; genetic drift=
unimportatn
Wright – genetic drift played important role in evolution
^CONTROVERSY IN EVOLUTIONARY BELIEFS
Importance of mechanism:
Mutation-selection balance
Mutation and strength of selection
Natural selection taking mutatuions out
Differet selective forces
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