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Lecture

Notes taken during lecture


Department
Biology
Course Code
BIO120H1
Professor
Jean Jiang Nash

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LECTURE 03:
Glucose transport tutorial today
Membrane transport of small molecules
More than one type of proton pump Ptype ATPas
Will need these three transporters 5
6 blue outside; orange inside
Epithelial cells have epithelial polarity top of picture microvilli, to increase SA, reaching
into lumen of intestine on apical side of cell lateral domains down the sides; basal
domains
Important to have a barrier to control what comes in and out of lumen transport proteins
on apical side decide what comes in and what doesnt selective process
Tight junction thus do not pass between the cells nothing can pass in between even
water cannot move cell decides what moves
7 green proteins do not move down to basallateral domain proteins can move lateral but
cannot move past tight junction
-restricted by tight junctions
- Na+/glucose symporters
-GLUT2 uniporter and Na+/K+ pump
8 more glucose in cytosol than lumen of epithelial so glucose will move down
concentration gradient
Symporter two molecules moved in same direction
-High Na+ in lumen
-Low Na+ in grey area
Passive transport of glucose through GLUT2 uniporter glucose escapes cell into
interstitial fluid passively
Driving force comes from sodium potassium pump using ATP hydrolysis energy to move
sodium into cell and potassium out of cell
High Na+ in light blue region
GLUT2
9- B
10 C
11- C
12 circled are protein complexes
13 V0type uses energy from ATP hydrolysis to pump protons past membrane
High concentration on 2H+ side
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