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Lecture

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Department
Biology
Course Code
BIO120H1
Professor
Jean Jiang Nash

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LECTURE 8 Feb.1.2011
Sorting and packaging
Depending on cell can have one Golgi or more if cell involved in secretion, can have 100
Golgi apparatus
ER sends transport vesicles to ER, fuse together, form cis Golgi structure
Sorting mechanism that occurs in transGolgi network
Bud from ER exit sites
Bound by cargo receptors
Resident ER protein stays in ER
Chaperone proteins responsible for holding misfolded or unfolded protein in ER
Know specific names of these chaperones
Cargo from ER to cisGolgi network
COPII-coated vesicles
oVesicular tubular cluster attached by motor proteins to microtubule
migrate towards Golgi
oShed COPII coat
oSNAREs involved in vesicle fusion
oTransport vesicles
oVesicular tubular cluster becomes the cis Golgi network
Retrograde transport recovering the proteins that should be in ER, but somehow left
Escaped ER-resident proteins
Proteins involved in vesicle budding from ER
oV-SNAREs, Rab-GTPAses, etc.
Retrieval of ER-resident proteins
Soluble with KDEL signal
oSignal that brings it back into ER if it escapes
oBound by KDEL receptor
oFour amino acids
KKXX pointing to the Y receptor attached to blue labelled COPI coat
oSignal bound by COPI coats
KDEL receptor recognizes the Er-resident proteins in Golgi returns them to ER
KDEL receptor coming back towards ER releases it to the ER and then goes back
to Golgi, empty
Recycling
Receptor doesnt want to bind to KDEL in ER, but does in the Golgi
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Description
LECTURE 8 Feb.1.2011 Sorting and packaging Depending on cell can have one Golgi or more if cell involved in secretion, can have 100 Golgi apparatus ER sends transport vesicles to ER, fuse together, form cis Golgi structure Sorting mechanism that occurs in transGolgi network Bud from ER exit sites Bound by cargo receptors Resident ER protein stays in ER Chaperone proteins responsible for holding misfolded or unfolded protein in ER Know specific names of these chaperones Cargo from ER to cisGolgi network COPII-coated vesicles o Vesicular tubular cluster attached by motor proteins to microtubule migrate towards Golgi o Shed COPII coat o SNAREs involved in vesicle fusion o Transport vesicles o Vesicular tubular cluster becomes the cis Golgi network
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