Class Notes (921,249)
CA (542,492)
UTSG (45,882)
BIO (2,271)
BIO120H1 (1,175)
Lecture

Notes taken during lecture

3 Pages
75 Views

Department
Biology
Course Code
BIO120H1
Professor
Jean Jiang Nash

This preview shows page 1. Sign up to view the full 3 pages of the document.
LECTURE Feb. 8, 2011
***Read figure legends in textbook before class for next, next lecture***
Exocytosis
Lipids
Vesicles move to plasma membrane to deliver cargo, including lipids
oBring lipids from synthesis at ER to Golgi to vesicles
Membrane proteins
Secreted soluble proteins
2 types of exocytosis
Constitutive always on, always functional, default
oIf protein is synthesized into ER lumen and has only ER signal sequence,
now soluble protein, its default fault is to be secreted in constitutive
secretive pathway
oBe secreted
Regulated e.g. insulin
oThose vesicles stay in cytosol, wait for signal
Constitutive secretory pathway
No sorting signal ends up in cytosol
So default pathway sentence should be changed for proteins with a ER signal
sequence and no other sorting signal
Regulated secretory pathway
Vesicles sitting under plasma membrane, waiting for signal
Vesicles fuse with plasma membrane
Found as aggregates in TransGolgi network
Next slide
Fusing to release insulin
Beta cell in pancreas
Beta cells waiting under plasma membrane to release glucose
oImmediate response
oV. quick compared with gene transcription, translation, etc.
oInsulin looks like a big ball of precipitate
oComes apart in neutral pH environment now in acidic environment
oIncrease in Ca levels causes vesicles to fuse
ENDOCYTOSIS
Process of maturation depends on brining hydrolytic enzymes from
Must have acid hydrolyase to be lysosome
Two types
PHAGOCYTOSIS
www.notesolution.com

Loved by over 2.2 million students

Over 90% improved by at least one letter grade.

Leah — University of Toronto

OneClass has been such a huge help in my studies at UofT especially since I am a transfer student. OneClass is the study buddy I never had before and definitely gives me the extra push to get from a B to an A!

Leah — University of Toronto
Saarim — University of Michigan

Balancing social life With academics can be difficult, that is why I'm so glad that OneClass is out there where I can find the top notes for all of my classes. Now I can be the all-star student I want to be.

Saarim — University of Michigan
Jenna — University of Wisconsin

As a college student living on a college budget, I love how easy it is to earn gift cards just by submitting my notes.

Jenna — University of Wisconsin
Anne — University of California

OneClass has allowed me to catch up with my most difficult course! #lifesaver

Anne — University of California
Description
LECTURE Feb. 8, 2011 ***Read figure legends in textbook before class for next, next lecture*** Exocytosis Lipids Vesicles move to plasma membrane to deliver cargo, including lipids o Bring lipids from synthesis at ER to Golgi to vesicles Membrane proteins Secreted soluble proteins 2 types of exocytosis Constitutive always on, always functional, default o If protein is synthesized into ER lumen and has only ER signal sequence, now soluble protein, its default fault is to be secreted in constitutive secretive pathway o Be secreted Regulated e.g. insulin o Those vesicles stay in cytosol, wait for signal Constitutive secretory pathway No sorting signal ends up in cytosol So default pathway sentence should be changed for proteins with a ER signal
More Less
Unlock Document


Only page 1 are available for preview. Some parts have been intentionally blurred.

Unlock Document
You're Reading a Preview

Unlock to view full version

Unlock Document

Log In


OR

Don't have an account?

Join OneClass

Access over 10 million pages of study
documents for 1.3 million courses.

Sign up

Join to view


OR

By registering, I agree to the Terms and Privacy Policies
Already have an account?
Just a few more details

So we can recommend you notes for your school.

Reset Password

Please enter below the email address you registered with and we will send you a link to reset your password.

Add your courses

Get notes from the top students in your class.


Submit