Notes taken during lecture

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9 Feb 2011
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LECTURE โ€“ Feb. 8, 2011
***Read figure legends in textbook before class for next, next lecture***
Exocytosis
๎€Lipidsโ€
๎€Vesicles move to plasma membrane to deliver cargo, including lipids
oBring lipids from synthesis at ER to Golgi to vesicles
๎€Membrane proteinsโ€
๎€Secreted soluble proteinsโ€
2 types of exocytosis
๎€Constitutive โ€“ always on, always functional, default
oIf protein is synthesized into ER lumen and has only ER signal sequence,
now soluble protein, itโ€™s default fault is to be secreted in constitutive
secretive pathway
oBe secreted
๎€Regulated โ€ฆ โ€œe.g. insulinโ€
oThose vesicles stay in cytosol, wait for signal
Constitutive secretory pathway
๎€No sorting signal โ€“ ends up in cytosol
๎€So default pathway sentence should be changed โ€œfor proteins with a ER signal
sequence and no other sorting signalโ€
Regulated secretory pathway
๎€Vesicles sitting under plasma membrane, waiting for signal
๎€Vesicles fuse with plasma membraneโ€
๎€Found as aggregates in TransGolgi networkโ€
๎€Next slideโ€ฆ
๎€Fusing to release insulin
๎€Beta cell in pancreas
๎€Beta cells waiting under plasma membrane to release glucose
oImmediate response
oV. quick compared with gene transcription, translation, etc.
oInsulin looks like a big ball of precipitate
oComes apart in neutral pH environment โ€“ now in acidic environment
oIncrease in Ca levels causes vesicles to fuse
ENDOCYTOSIS
๎€Process of maturation depends on brining hydrolytic enzymes from
๎€Must have acid hydrolyase to be lysosome
Two types
๎€PHAGOCYTOSIS
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Document Summary

***read figure legends in textbook before class for next, next lecture*** vesicles move to plasma membrane to deliver cargo, including lipids: bring lipids from synthesis at er to golgi to vesicles. constitutive always on, always functional, default: if protein is synthesized into er lumen and has only er signal sequence, now soluble protein, it"s default fault is to be secreted in constitutive secretive pathway, be secreted. regulated e. g. insulin : those vesicles stay in cytosol, wait for signal. no sorting signal ends up in cytosol. so default pathway sentence should be changed for proteins with a er signal sequence and no other sorting signal . vesicles sitting under plasma membrane, waiting for signal. beta cells waiting under plasma membrane to release glucose. process of maturation depends on brining hydrolytic enzymes from. must have acid hydrolyase to be lysosome. phagocytosis www. notesolution. com: large vesicles that ingest large particles, microorganisms, dead cells .

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