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School
Department
Course
Lecture 10
Cell Communication: General Concepts and Principles
Cell Communication Through Signaling
oUnicellular organisms
Sense signals in growth environment
Eg. High [nutrients]
oMulticellular organisms
Complex signaling networks
Cells within organism carefully regulated
Why is Signaling Important? Example: Regulation of Cell Proliferation
oIf cell doesnt respond appropriately cancer
oChart of major signaling pathways relevant to cancer in human
cells (Figure 20-37)
oCancer misregulation of growth cells
oOveractive signals regulate proliferation
Why is Signaling Important? Example: Regulation of Cell Movement
oSlime Mold (unicellular)
Attracted to cAMP chemotaxis moves toward high
concentration of chemical
Signal for single cells to aggregate to form slug
oMicropipette with cAMP
Movement by extending a new pseudopod
Signal Molecules and Receptors
o1) Cell surface receptors
Bind to hydrophilic ligand
o2) Intracellular receptors
Bind to hydrophobic signaling molecules
Transported by carrier proteins in extracellular fluid and
deliver to cells
Because not soluble
Classes of Cell Surface Receptors in Animals
o1) Ion-Channel-linked receptors
(ligand gated ion channels)
Eg. Regulated by neurotransmitters
o2) G-protein-linked receptors (GPCR)
Largest family in animals
>800 genes in human genome
Receptors to visual, taste, smell, and many other
neurotransmitters
o3) Enzyme-linked receptors
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Document Summary

Lecture 10: cell communication through signaling, unicellular organisms. Example: regulation of cell movement: slime mold (unicellular)  attracted to camp chemotaxis moves toward high concentration of chemical.  signal for single cells to aggregate to form slug: micropipette with camp.  movement by extending a new pseudopod: signal molecules and receptors, 1) cell surface receptors.  bind to hydrophilic ligand: 2) intracellular receptors.  transported by carrier proteins in extracellular fluid and deliver to cells.  because not soluble: classes of cell surface receptors in animals, 1) ion-channel-linked receptors (ligand gated ion channels) Regulated by neurotransmitters: 2) g-protein-linked receptors (gpcr)  receptors to visual, taste, smell, and many other neurotransmitters: 3) enzyme-linked receptors www. notesolution. com.  cytosolic domain has enzymatic activity or is associated with an enzyme.  examples: receptor tyrosine kinases (rtks, tgfb receptor serine/threonine kinases, cytokine receptors (jak/stat pathway, 4) other receptors. *transmembrane domains; include protein degradation to activate pathway: cell surface receptors in plants, enzyme-linked receptors:

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