BIO120H1 Lecture 9: Lecture 9

Complete the following sentences to examine various components of the endomembrane system.

Information within the ____________ is transcribed into mRNA and transported outside the nuclear envelope.

Proteins, which are synthesized by ____________ , are then released into the ____________ , where they are further folded and modified.

The ____________ does not have attached ____________ and produces lipids, such as steroids.

Once proteins are folded and modified, transport vehicles called ____________ pinch off and surround them with membranes to be transported elsewhere.

The vesicles are moved to the ____________ where they are sorted and packaged.

Transport vehicles called ____________ carry the macromolecules to the ____________ where they fuse and release their contents to the outside environment.

ribosomes

Golgi apparatus

smooth endoplasmic reticulum

vesicles

plasma membrane

rough endoplasmic reticulum

nucleus

secretory vesicles

Which of these are ways cells can move across membranes? (check all the apply)

1. chaperones

2. active transporters

3.permeases

4. secretory vesicles

Which compartments are involved in vesicular transport? How are transport vesicles formed and targeted appropriately? What proteins are involved and what are their roles? What kinds of modifications are added to proteins in the ER? What determines whether a protein stays in the ER or moves on? Be sure to understand how vesicles fuse with their target membranes, and the consequences of fusion for the vesicle’s cargo as well as the proteins and lipids that are in the membrane. Know the structure of the Golgi apparatus and its role in intracellular trafficking. Understand the secretory process, endocytosis, exocytosis, function of the endosomes, and function of the lysosomes. Understand why endocytosis happens and how it can be regulated to take up specific molecules.