BIO120H1 Lecture : Notes taken during lecture

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2 Mar 2011
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BIO120H1 Full Course Notes
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BIO120H1 Full Course Notes
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Myosin i i made up of six proteins. coiled-coil motif of the heavy chain long string with globular domains at the ends. Light chains regulate activity of globular domains, which are for walking . acts as a motor because of experiments: myosin motors attached to glass slide, microfilaments bound by heads, add atp and observe movement, atp-dependent because if no atp, myosin binds to head but doesn"t move. biding doesn"t require atp, but movement does. conformation change in the head: lose high affinity for actin, so actin filament released, is reduced , atp hydrolyses . 5nm to the next monomer down the filament towards the plus end : still not bound to filament, but physically moved to plus end. distance between z disc and z disc is a sarcomere: z discs pulled together this is a muscle contraction, release z discs spring apart www. notesolution. com. will spring apart completely if not for titin.

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