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Lecture

Notes taken during lecture

4 Pages
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Department
Biology
Course Code
BIO120H1
Professor
Jean Jiang Nash

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LECTURE 16 March 8th
Anchoring junctions continued.
SELECTINS the next type of anchoring junctions
Type of lectin
Lectins are carbohydrate-binding domains
To oligosaccharides on other cells
Not catenins in this case dont need to know the actual name
Also clustered giving interaction high avidity strong Velcro interaction
Blood vessel
Cells secrete yellow stuff, which cells stick to
Epithelium lined blood vessel = endothelium
Rolling on cells because of infection
oSecreting signal received by endothelial cells in nearby blood vessel, which
begin to express p-selectin which is now sticking out of membrane, and
start to attract or stick to the cells,
Rolling is selectin-dependent
Sticking mechanism based on integrins
Weak adhesion and rolling on selectins strong adhesion and
integrins
Cells will move in between endothelial cells and
Extravization ?
DRAW TABLE to summarize
Other anchoring junctions
Immunoglobulin superfamily
oThese proteins have immunoglobulin domain
oImmunoglobulin = antibody
oAntibody made up of those Ig domains
oCD4 = ex. of immunoglobulin superfamily protein
oMultiple Ig-like extracellular domains
oMediate calcium-independent, homophilic or heterophilic receptor
interactions
DESMOSOMES
Like adherence junction
Like cadherin like proteins outside cell but inside cell, linked to intermediate
filaments, instead of actin
Bind intermediate filaments
Adaptor proteins linking adhesion complex to intermediate filaments not
catenins, different proteins
Strengthening tissues
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Description
th LECTURE 16 March 8 Anchoring junctions continued. SELECTINS the next type of anchoring junctions Type of lectin Lectins are carbohydrate-binding domains To oligosaccharides on other cells Not catenins in this case dont need to know the actual name Also clustered giving interaction high avidity strong Velcro interaction Blood vessel Cells secrete yellow stuff, which cells stick to Epithelium lined blood vessel = endothelium Rolling on cells because of infection o Secreting signal received by endothelial cells in nearby blood vessel, which begin to express p-selectin which is now sticking out of membrane, and start to attract or stick to the cells, Rolling is selectin-dependent Sticking mechanism based on integrins Weak adhesion and rolling on selectins strong adhesion and integrins Cells will move in between endothelial cells and Extravization ? DRAW TABLE to summarize Other anchoring junctions Immunoglobulin superfamily o These proteins have immunoglobulin domain o Immunoglobulin = antibody o Antibody made up of those Ig domains o CD4 = ex. of immunoglobulin superfamily protein o Multiple Ig-like extracellular domains o Mediate calcium-independent, homophilic or heterophilic receptor interactions DESMOSOMES Like adherence junction Like cadherin like proteins outside cell but inside cell, linked to intermediate filaments, instead of actin Bind intermediate filaments Adaptor proteins linking adhesion complex to intermediate filaments not catenins, different proteins Strengthening tissues www.notesolution.com
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