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15 Mar 2011
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LECTURE 18
Elastin
Flexible tissues (ex. blood vessels, lungs)
oLungs stretches, inflating ECM full of elastin fibres
oGreen proteins linked covalently so when stretch out, will not separate
oCoil and stretch and coil and stretch
Self-assemble into elastic network outside cell
Basal lamina
Thin and flexible
Basal surface of epithelial cells attached to it via focal adhesion contact
Lumen is always apical and also apical is outside body
Figure 19-53 KNOW IN DETAIL
oFibroblast can migrate not just white blood cells
oBoth have ability to modify ECM by secreting and modifying activity of
proteases
Blistering diseases when basal lamina doesnt function properly
Muscular dystrophy muscle loses attachment
When cannot attach cells properly to basal lamina, disease result
Physical attachment comes through transmembrane protein
Fibronectin and laminin are linker proteins
Link ECM to transmembrane proteins on cell surface
Laminin
Molecule made of 3 proteins
Folded into coiled coil
Heterodimer
What is interacting with what?
oSelf assembly is how laminin stick to laminin to form large complexes
oIntegrin and laminin attach to lamin to matrix
oDystroglyan can perlecan are what
Binds to Type IV collagen, perlecan and nidogen
Binds to integrins
ECM and cell surface fibronectin
Important during gastrolation
B is fibronectin dimer held together by disulfide bridges
Two forms
oSoluble form found in blood
If cut self, activated to form network clotting
oFibrilar form normal form involved in cell to matrix interactions in
normal tissues
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