BIO120H1 Lecture : Tutorial notes
36
BIO120H1 Full Course Notes
Verified Note
36 documents
Document Summary
Cancers result when cells lose contact with neighbours, or lose control of cell cycle, or cannot die because of constant propagation. To combat cancer we must understand what leads to cancer at the level of molecules. enlarges, duplicates chromosomes, and separates into two cells. In yeast, decision to divide or not to divide based on nutrient availability: if enough, then divide. g0 = way for cell to exit cell cycle, if it lacks mitogen telling it to divide. many checkpoints in cell cycle: questions asked include about dna damage (blocked if dna damage); replication doesn"t finish if dna damage, can stop to repair; entrance into. M, dna must be completely replicated; anaphase blocked if chromosomes not aligned up on metaphase plate. r point is misregulated in cancer: mitogens gone, cell stops dividing, but once cell pases restriction point, entire process is autonomous. once enter r point, rest of cycle must occur or die.
