Class Notes (859,838)
CA (520,906)
UTSG (45,056)
BIO (2,244)
BIO120H1 (1,174)
Lecture

Tutorial notes

2 Pages
116 Views

Department
Biology
Course Code
BIO120H1
Professor
Jean Jiang Nash

This preview shows 80% of the first page. Sign up to view the full 2 pages of the document.
Description
Bens Story case of retinoblastoma Cancers result when cells lose contact with neighbours, or lose control of cell cycle, or cannot die because of constant propagation To combat cancer we must understand what leads to cancer at the level of molecules Cell cycle Enlarges, duplicates chromosomes, and separates into two cells Must be tightly controlled with checkpoints In yeast, decision to divide or not to divide based on nutrient availability o If enough, then divide In mice, nutritional and cell-cell communication through contact and receptors and signals that feed into cell cycle clock o They include tyrosine kinase receptors, G-protein coupled receptors, TGF- beta receptors, integrins, nutrient status o All feed into molecular machine, used by cell to deicde whether to enter into G0 or enter into cell cycle o This decision is screwed up in cancer o When enter cell cycle, must finish or die o Entering is the big decision for the cell G0 = way for cell to exit cell cycle, if it lacks mitogen telling it to divide Many checkpoints in cell cycle o Questions asked include about DNA damage (blocked if DNA damage); replic
More Less
Unlock Document
Subscribers Only

Only 80% of the first page are available for preview. Some parts have been intentionally blurred.

Unlock Document
Subscribers Only
You're Reading a Preview

Unlock to view full version

Unlock Document
Subscribers Only

Log In


OR

Don't have an account?

Join OneClass

Access over 10 million pages of study
documents for 1.3 million courses.

Sign up

Join to view


OR

By registering, I agree to the Terms and Privacy Policies
Already have an account?
Just a few more details

So we can recommend you notes for your school.

Reset Password

Please enter below the email address you registered with and we will send you a link to reset your password.

Add your courses

Get notes from the top students in your class.


Submit