BIO130H1 Lecture Notes - Lecture 4: Translocon, Collagen, Endomembrane System

• School: UTSG
• Department: Biology
• Course: BIO130H1
• Professor: Melody Neumann

Document Summary

Transporter proteins: some do passive transport glut uniporter, some do active transport na+/glucose symporter -> na+/k- pump. Transport proteins work together to transfer glucose from the intestine to the blood stream. Lumen where the food goes: villi lines the intestine and increases the surface area and each villus contains lots of epithelial cells. Glucose from the lumen -> into the blood stream. Glucose has to pass through epithelial cells -> goes from low concentration in the lumen in the intestine to high concentration in the cytosol of the epithelial cells and back to low concentration in the blood. Extracellular fluid on the basolateral side of the epithelial cell. To keep na+ low inside the cell, there is a na+/k+ pump. Gl cannot be in the apical side therefore proteins need to be on the proper side. Transcellular transport of glucose requires the asymmetric distribution of membrane proteins. Intestinal epithelial cells: transport proteins restricted by tight junctions.