BIO130H1 Lecture Notes - Lecture 14: Basal Lamina, Tight Junction, Gap Junction
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BIO130H1 Full Course Notes
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Document Summary
Cells are organized into tissues (refer to slide 2 for diagram: at the top are the epithelial tissues where the cytoskeletons in adjacent cells are connected to each other through junctions. This gives the sheet as a whole strength rather than individual cells strength: underneath this epithelial sheet is the basal lamina. It is produced and secreted by the epithelial cells. The epithelial tissues are also connected into the basal membrane through special junctions that link the cytoskeleton in the cell across the membrane into the basal membrane. Not only is the sheet strong because of its contact between cells but it is also attached to something, making it hard to pull it off from its underlying tissue: underneath the basal lamina is some connective tissue. Connective tissue is very different from the epithelial sheet: there are fewer cells and they tend not to be connected to each other but they are connected to the extracellular matrix.
