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BIO130H1 Lecture Notes - Lecture 6: Ultraviolet, Antibiotics, Stra

The building blocks of life page 2 single rna continuously discontinuously. Parental helices are pulled apart this direction -------> The building blocks of life page 7 telomeres. The ends get tucked back into the 5" end. Can be extended or it can be shorter. Polymerase continues from the -oh group from the 3" Extends the template onto the 3" end (alpha) Typically, in humans, all cells have telomeres but not in high amounts so telomeres get shorter and shorter. Only some have active telomeres like skin cells, bone marrow. Replication senescence - telomere is too short for replication. In cancer cells, there are a lot telomerase. Every 10 bases, you need an extra turn. Rotate around the sugar-po4 backbone of one strand. Typically operates just in front of the helicase. Notice the change in shape of the topoisomerase. One ds helix to pass through to other. Inhibit topoisomerism - no dna replication - can"t unwind.

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BIO130H1 Lecture Notes - Lecture 6: Ultraviolet, Antibiotics, Stra

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