BIO130H1 Lecture Notes - Lecture 3: Opioid Peptide, Alpha Helix, Hydrogen Bond
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O polypeptide chain becomes carbonyl carbon becomes amide nitrogen main chain/peptide backbone = everything except for the. Note: sometimes, 1 polypeptide chain is a protein, while other times, many polypeptide chains constitute a protein. The order of amino acids is important: this is leu-enkephalin (a pentapeptide of tyr-gly-gly-phe-leu, note that if not stated, you can automatically assume that the left end is the n- terminus and the right end is the c-terminus. It is a natural opioid peptide which down regulates the perception of pain. Thursday, january 11th, 2018: however, the pentapeptide leu-phe-gly-gly-tyr has no pharmacological effects since the nh2 cooh orientation of the peptide is essential for function. R-group/sidechain does not form the h-bonds/stabilize the alpha helix formed with an amino acid 4 amino acids away. Purple = r group: h-bonds, again, stabilize the beta sheet, r-groups do not form the h-bonds/stabilize the beta sheet.