BIO130H1 Lecture Notes - Lecture 12: Aminoacyl-Trna, Endoplasmic Reticulum, Peptide Synthesis

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9 Mar 2020
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BIO130H1 Full Course Notes
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BIO130H1 Full Course Notes
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Overview of the catalytic process for amino acid addition. The ribosomes are free in the cytoplasm. The ribosomes can be free in the cytoplasm (cytosol) The a, p, and e sites are embedded in the ribosomes. The peptide bonds are taken place in the peptidyl transferase activity center of the ribosome. Example of a ribozyme in which rna does catalytic work. Even though ribosomes are made up of proteins, the rna is actually doing the catalytic work. The mrna is fed in through the ribosome which is there the peptide bonds are formed at the peptidyl transferase activity center. What happens is that the ribosome needs to move forward 3 nucleotides at a time. The small subunit and the large subunit are moving relative to each other. The large ribosomal subunit moves forward on the rna by 3 nucleotides. Now the e, p, and a sites are tilted and not aligned anymore.

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