BIO130H1 Lecture Notes - Lecture 7: Transcription (Genetics), Deoxyribose, Ribose

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BIO130H1 Full Course Notes
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Chapter 6: how cells read the genome: from dna to protein: when the cell needs a particular protein, the nucleotide sequence of the appropriate portion of the. All cells express their genetic information in this way a fundamental principle called the central dogma of molecular biology. Portions of dna sequence are t ranscribed into rna: like dna, rna is a linear polymer made of four different types of nucleotide subunits linked together by phosphodiester bonds. Since u, like t, can base-pair by h- bonding with a: dna is a ds-helical molecule, whereas rna is ss (but can fold into a ds shape) Instead, the rna chain is displaced and the dna helix re-forms. template-dependent nucleotide polymerizing enzymes seem to have arisen independently twice during the early evolution of cells. In eukaryotes, a transcription unit typically carries the information of just one gene. Dna template as a guide: a detachable subunit called sigma (

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