BIO130H1 Lecture Notes - Lecture 9: Ribose, Cytoplasm, Chromosome

• School: UTSG
• Department: Biology
• Course: BIO130H1
• Professor: Kenneth Yip

Document Summary

Bio130 lecture 9 dna errors continued. In eukaryotes: post-polymerase error repair process, initiated by detection of distortion in the geometry of the double helix generated by mismatched basepairs this case, muts and mutl) After an error in a newly-made strand, mismatch proofreading proteins bind (in. Dna scanning detects nick in new dna strand. Strand is removed, and then repair dna synthesis occurs. Even after synthesis, dna can get damaged and need repair. Defects in repair mechanisms have been linked to a variety of human diseases. This is the case because these tissues are reproducing very quickly: epithelial layers, sometimes not enough time to detect a mutation in the dna. As well as other cell stressors: spontaneous cell damage can also occur. All daughter cells of the mutant tissue will have the mutation as well. This is a big problem in fast-replicating cells like cancer cells. If uncorrected, mutations now appear in daughter cells.