BIO130H1 Lecture Notes - Lecture 18: Golgi Apparatus, Endoplasmic Reticulum, Signal Peptidase

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18 Mar 2016
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BIO130H1 Full Course Notes
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BIO130H1 Full Course Notes
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Bio130 lecture 18 signals and sorting. Translation starts on cytosolic ribosomes: this is co-translational translocation to the er, this is very expensive, companies compete for our money. For n-terminus, the signal peptidase can remove the signal sequence from the protein. It would take too many scientists to keep track of, store, move, and test millions of chemicals and proteins. Can be internal stretches of aa which remain part of the protein. Signal sequence at the amino-terminal end directs the protein to the er. Signal sequence cleaved, left behind in the er membrane, secreted protein ends. Secreted protein moves in transport vesicles via the secretory pathway. Either steps 1, 2, 3; or steps 1, 2a, 3a, 4a. Hydrophobic transmembrane segment is an internal signal sequence. Ribosomes bind to mrna and make protein as per usual at the end terminus. Eventually you make internal signal sequence, at which point srp takes. N-terminus faces the er lumen and c-terminus faces cytosol.

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