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Lecture 21

BIO130H1 Lecture Notes - Lecture 21: Basal Lamina, Hyaluronic Acid, EpitheliumPremium


Department
Biology
Course Code
BIO130H1
Professor
Kenneth Yip
Lecture
21

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BIO130 – Lecture 21 – Tissues and ECM
Monday, March 28, 2016
Preamble
-In multiple sclerosis, the fatty myelin sheaths around the axons of brain and
spinal cord cells are damaged
-2-150 in 100,000 people get this disease
Cells are organized into tissues
-Tissue organization in human skin
oNucleus is surrounded by cytosol
oCells are in close contact with each other
-Epithelial tissue lines things, and connective tissue lies underneath
-Basal lamina lies between them
oThis is a specialized extracellular matrix
oSometimes, it is included as epithelial tissue
Compare and Contrast
-Epithelial tissue
oE.g. intestinal lining, skin epidermis
oCells closely related
oLimited ECM
A thin basal lamina
oCytoskeletal filaments provide resistance to mechanical stress
oCells are attached to each other
-Connective tissue
oE.g. bone, tendon
oCells are rarely connected
oPlentiful ECM
oECM provides resistance to
mechanical stress
oCells are attached to the matrix
oOften underlies an epithelium
In the ECM, many
specialized structures
and proteins
Extracellular Matrix
-Connective tissues
oE.g. dermis, bone, tendon
oComposed of extended fibrous proteins
-Different composition of ECM
oGives tissues different properties
-Not a static structure
oRemodeled over time
ECM Organization
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Collagen provides tensile strength
-Resists pulling forces
-Secreted by fibroblasts, epithelial, and smooth muscle cells
-Fibriallar collagens form rigid cables
-Generally these cables were composed of three chains wound around each other
in a triple helix
Proteoglycans are space filling
-Proteins modified with glycosaminoglycans (GAG)
oGAG: long, linear chains of a repeating disaccharide
oHighly negatively charged
Attract Na+ and water
-All proteoglycans are glycoproteins, but not the other way around
-One of the sugars is an amino sugar
Hyaluronan
-A simple GAG
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