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BIO220H1 Lecture Notes - Umbilical Artery, Decidua, Umbilical Vein

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Integrative Physiology I
2 real life scenarios: pregnancy and birth together with exercises
Pregnancy and birth
Conception- pregnancy- lactation
Reproductive system highly regulated by hormones egg or ovum once
ovulated 72hours life
Sperm 120 hours life
Egg release to ovary to fallopian tube through chemotaxis
Fertilization Day 1 egg still in fallopian tube after fertilization
zygote form as it travel cleavage occurs continuously large spherical
mass morla
Blastocysts pass to 5-9 days after fertilization
Changes in lining of lining of uterus during reproductive cycle-
endometrium goes to repeated changes
During follicular phase endometrium proliferates and thickens and
there is devpt of endometrial glands secrete clear fluid in uterus
implantation now must occure
Blastocyst attaches to lining of uterus have rich capilliary network
Trophoblasts cells surround the blastocysts and this is the first point
of contact bet.endometrial cells and the lining. Trophoblasts cells invade

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Endometrium can support trophoblast cell
Trophoblast cell produce enzymes
Cytotrophoblasts remains close
Synciotiotrophoblast invade into endometrium
Have many processes similar to cancer cells
Endometrium produces prostaglandins ac causes edema w/c further
facilitates invasion process
Human and non human primate plantation is complete
Interstitial implantation
Eccentric implantation implantation not complete
Why does mother not reject embryo/fetus?
Trophoblasts incade deciduas form interphase bet.mother and child
not ecpress antigens
Mother not generate antibodies to fetus
Maternal immunosuppresion leads to dec. maternal antibody
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