BIO220H1 Lecture Notes - Lecture 10: Adaptation, Twin Study, Hepatitis B Virus

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28 Oct 2012
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BIO220H1 Full Course Notes
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BIO220H1 Full Course Notes
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The phage in bacteria is what is toxic when you get a shot, you get a piece of that phage. Jenner discovered that milk maids were immune to smallpox. Milk maids instead acquired cow pox, which gave immunity to small pox. Vaccines should be created as a selective force on a pathogen itself. If there is selection against one type by this vaccine, then the other type should increase this frequency. If you have a pathogen that has many variants, it will be difficult to create a vaccination. We do selection experiment and we favour a variant that is actually beneficial to treating the disease. Not all infectious diseases are the same. Develop acute characteristics that either kill the host quickly or are easily cleared. Pathogens are still out there because they are exploiting susceptible individuals such as children who have never been exposed.

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