BIO230H1 Lecture Notes - Lecture 11: Mannose, Endosome, Lysosome
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BIO230H1 Full Course Notes
Verified Note
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Document Summary
Proteins sorted to the er are transported to other destinations via vesicular transport. Trans golgi network (tgn) faces away from er. Cis cisterna, medial cisterna and trans cisterna: cisterna between cis face and trans face of golgi. Cargo packaged in copii-coated vesicles bud from er exit sites. Cargo contains exit signals: soluble protein: bound by cargo receptors, transmembrane protein: bound by copii coat, other cargos have no exit signal, but are packaged because of high concentrations in er. Copii-coated vesicles bud from er exit site: sheds copii coat, fuses with each other to form vesicular tubular clusters. Vesicular tubular clusters move to golgi apparatus. Retrieval transport by copi-coated vesicles: vesicles from vesicular tubular clusters and golgi to er. Vesicles to contain: escaped er resident proteins, proteins involved in vesicle budding from er. Many er resident proteins have er retrieval signals. Soluble er proteins: have kdel (amino acid) signal, packaged into copi-coated transport vesicles.
