BIO230H1 Lecture Notes - Lecture 6: Transcriptome, Transferrin Receptor, Aconitase
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BIO230H1 Full Course Notes
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Readings (alberts et al. , custom text) pages 72-82; 122-129. During transcription elongation the c-terminal domain (ctd) of rna polymerase binds rna processing proteins and transfers to rna at appropriate time. Binding of rna processing proteins is regulated by of rna polymerase (speci cally of c-terminal tail) phosphorylation. Diff cterm phosphorylation states bind to diff enzymes/protein. The cell selectively transports mature mrna from the nucleus. Markers of mature mrna - must be acquired for export cap binding complex (cbc) exon junction complex (ejc) indicates proper processing poly-a-binding proteins. These proteins travel with the mrna to the cytosol. Markers of immature mrna must be lost for export proteins involved in rna splicing (eg prna) The cell selectively transport mature mrna from the nucleus. Improperly processed mrnas will eventually be degraded in the nucleus by the exosome. Nuclear transport can also be regulated eg. human aids virus hiv retrovirus genome encoded by rna; packed into virus molecule (2.
