BIO230H1 Lecture Notes - Lecture 15: Adherens Junction, Tight Junction, Intermediate Filament
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Cells are organized into one of two main tissue categories. Epithelial tissue lines cavities, surfaces and surrounds organs. More than 60% of cell types in our bodies. Connective tissue lots of ecm providing overall structure; whereas in the epithelial tissue the cells are connected very closely, here, cells are spaced out. Epithelial structure & function requires junctional complexes (other cells may have junctions, but epithelial cells must have them: occluding junction blocks things, tight junctions seals gaps between epithelial cells. Sealing strands formed from multiple tight junctions: claudins and occludin proteins. Both are 4-pass transmembrane proteins: cell-cell anchoring junctions, adherens junctions connect actin filament bundles in one cell with that in the next cell; can form adhesion belts. Ecm: hemidesmosomes anchors intermediate filaments in a cell to the ecm. Adherens junctions can form adhesion belts (ie. many adherens junctions) Cadherin proteins cell-cell anchoring protein; these are transmembrane proteins that reach to the inside (cytosol) of cells.