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Lecture 5

Lecture 5.pdf

23 Pages
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Department
Biology
Course Code
BIO270H1
Professor
Chris Garside

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Lecture 5
October 11, 2013
12:05 PM
BIO270 Page 1
Do not have to memorize the pathways
What goes in, what comes out,
How are they regulated
Don’t have to know the imtermediates, conmplexes etc.
Maybe a couple of enzymes.
What do they do?
Converting an extracellular signal to an intracellular signal
A response to inside the cell
A messenger was produced outside that cell which is receiving that
message.
There are 4 components.
The intracellular
Molecule.
Transducer: Transmembrane domain and the intracellular
domain asomehow modifies their structure so they can
itneract and activate the intracellular moelcule.
<-- then the orgnaism only has to synthesize / doesn’t have to
synthesize as much as of the messenger. Cascade. Phosphorylation
or second messenger cascade. One ligand leads to thousands of
phosphorylation molecules.
BIO270 Page 2
Amplification, this is important
If you have one ligand here, it may acitvate 10 moelcules of active
substane A. each pf these 10 substance A might 10 substance B
which will activate 10 subsbtance C. so from one extracellular
ligand you have 10 substance C which would lead to massive
changes inside the cell.
BIO270 Page 3

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Description
Lecture 5October 11 20131205 PM BIO270 Page 1 Do not have to memorize the pathwaysWhat goes in what comes out How are they regulatedWhy is it importantDont have to know the imtermediates conmplexes etcMaybe a couple of enzymesWhat do they doConverting an extracellular signal to an intracellular signal A response to inside the cellA messenger was produced outside that cell which is receiving that messageThere are 4 componentsTransducer Transmembrane domain and the intracellular domain asomehow modifies their structure so they can itneract and activate the intracellular moelculeThe intracellular Moleculethen the orgnaism only has to synthesizedoesnt have to synthesize as much as of the messenger Cascade Phosphorylation or second messenger cascade One ligand leads to thousands of phosphorylation moleculesBIO270 Page 2
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