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Lecture 5

Lecture 5.pdf


Department
Biology
Course Code
BIO270H1
Professor
Chris Garside
Lecture
5

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Lecture 5
October 11, 2013
12:05 PM
BIO270 Page 1

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Do not have to memorize the pathways
What goes in, what comes out,
How are they regulated
Don’t have to know the imtermediates, conmplexes etc.
Maybe a couple of enzymes.
What do they do?
Converting an extracellular signal to an intracellular signal
A response to inside the cell
A messenger was produced outside that cell which is receiving that
message.
There are 4 components.
The intracellular
Molecule.
Transducer: Transmembrane domain and the intracellular
domain asomehow modifies their structure so they can
itneract and activate the intracellular moelcule.
<-- then the orgnaism only has to synthesize / doesn’t have to
synthesize as much as of the messenger. Cascade. Phosphorylation
or second messenger cascade. One ligand leads to thousands of
phosphorylation molecules.
BIO270 Page 2

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Amplification, this is important
If you have one ligand here, it may acitvate 10 moelcules of active
substane A. each pf these 10 substance A might 10 substance B
which will activate 10 subsbtance C. so from one extracellular
ligand you have 10 substance C which would lead to massive
changes inside the cell.
BIO270 Page 3
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