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Lecture 3

BIO270H1 Lecture Notes - Lecture 3: Van Der Waals Force, Lipid Raft, Equilibrium Constant

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Chris Garside

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Bio270 September 26, 2012
Reducing Energy
o Reducing energy
o Redox Status
High Energy Bonds
o ATP is stored in a stable level in cells. 5mM in muscle cells
o High AcetylCoA = High energy in cells
Mito Oxidative Metabolism
o AcetylCoA is the main point of entry for mitochondrial energy producing pathways.
TCA cycle
o 1 gtp is equivalent of 1 atp molecule
o Amphibolic pathway = anabolic and catabolic
o Series of redox reactions as electrons are passed from one place to another.
o 3 complexes use energy from oxidation of nadh and nadh2 from the protons to pump
energy, in order to produce ATP from ADP-Phosphorylation.
ATP Synthesis
o Link through proto-motive force and not physically link.
Integration of Metabolic Pathways
o ATP and oxygen is needed for energy to utilize from mitochondria.
o High energy stimulates anabolic pathways, while low energy stimulates catabolic
Cellular Membranes
o Glyco-lipids are found outside of the membrane
Membrane structure
o Amphipatic both hydrophilic and hydrophobic
Liquid profile affects membrane properties
o Cholesterol enhances fluidity at low temperature, while inhibits fluidity at high
If both molecules are squeezed together, Van der waals force increases.
Membrane Heterogeneity
o Lipid rafts
Temp and membrane fluidity
o Cold temperature increase van der waals forces between lipids and restrict movement,
while warm temperature decreases van der waals forces and causes movement.
Membrane proteins
o Two types
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